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Heterosynaptic eLTD takes place at synapses adjacent on the stimulated synapses. As an example, stimulation of Schaffer collaterals in hippocampal CA1 brings about a persistent reduce in GABAergic inhibition of CA1 pyramidal neurons (106). The system of eLTD at hippocampal inhibitory synapses seems to have to have inhibition of adenylyl cyclase as